Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action
Antiallergic activities of 10 lactic acid bacteria strains prepared from Mongolian dairy products as orally administered probiotics were examined in three murine type I allergy models (compound 48/80 stimulation, passive cutaneous anaphylaxis reaction, and ovalbumin sensitization models). Among the...
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doaj-00d50cad536b4ab18fbbbae742a68caf2021-04-29T04:42:33ZengElsevierJournal of Functional Foods1756-46462014-07-0196069Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic actionShiro Takeda0Muneaki Hidaka1Hiroki Yoshida2Masahiko Takeshita3Yukiharu Kikuchi4Chuluunbat Tsend-Ayush5Bumbein Dashnyam6Satoshi Kawahara7Michio Muguruma8Wataru Watanabe9Masahiko Kurokawa10Research Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo, Miyazaki 885-0003, JapanDepartment of Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, JapanDepartment of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, JapanResearch Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo, Miyazaki 885-0003, JapanResearch Division, Minami Nihon Rakuno Kyodo Co., Ltd., 5282 Takagi, Miyakonojo, Miyazaki 885-0003, JapanFood and Biotechnology School, Mongolian University of Science and Technology, Ulaanbaatar 15160, MongoliaMongolian Biotechnology Association, Ulaanbaatar 15160, MongoliaDepartment of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibananishi, Miyazaki, Miyazaki 889-2192, JapanDepartment of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibananishi, Miyazaki, Miyazaki 889-2192, JapanDepartment of Microbiology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, JapanDepartment of Biochemistry, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino, Nobeoka, Miyazaki 882-8508, Japan; Corresponding author. Tel.: +81 982 23 5574; fax: +81 982 23 5684.Antiallergic activities of 10 lactic acid bacteria strains prepared from Mongolian dairy products as orally administered probiotics were examined in three murine type I allergy models (compound 48/80 stimulation, passive cutaneous anaphylaxis reaction, and ovalbumin sensitization models). Among the 10, only Lactobacillus plantarum strain 06CC2 significantly alleviated allergic symptoms in all three models and reduced the levels of total IgE, ovalbumin-specific IgE, and histamine in the sera of ovalbumin-sensitized mice. In vitro study, interferon-γ and interleukin-4 secretions from spleen cells of ovalbumin-sensitized mice administered the 06CC2 strain were significantly enhanced and suppressed, respectively, in the presence of ovalbumin. In Peyer's patches of ovalbumin-sensitized mice, strain 06CC2 significantly enhanced mRNA expressions of interferon-γ and interleukin-12 receptor β2, but suppressed that of the interleukin-4. Thus, strain 06CC2 probably promoted Th1 immunity through intestinal immunity and improved the Th1/Th2 balance in type I allergic mice, resulting in alleviation of allergic symptoms.http://www.sciencedirect.com/science/article/pii/S1756464614001467Type I allergyProbioticsMast cellsTh1/Th2 balanceCytokinePeyer's patches |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shiro Takeda Muneaki Hidaka Hiroki Yoshida Masahiko Takeshita Yukiharu Kikuchi Chuluunbat Tsend-Ayush Bumbein Dashnyam Satoshi Kawahara Michio Muguruma Wataru Watanabe Masahiko Kurokawa |
spellingShingle |
Shiro Takeda Muneaki Hidaka Hiroki Yoshida Masahiko Takeshita Yukiharu Kikuchi Chuluunbat Tsend-Ayush Bumbein Dashnyam Satoshi Kawahara Michio Muguruma Wataru Watanabe Masahiko Kurokawa Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action Journal of Functional Foods Type I allergy Probiotics Mast cells Th1/Th2 balance Cytokine Peyer's patches |
author_facet |
Shiro Takeda Muneaki Hidaka Hiroki Yoshida Masahiko Takeshita Yukiharu Kikuchi Chuluunbat Tsend-Ayush Bumbein Dashnyam Satoshi Kawahara Michio Muguruma Wataru Watanabe Masahiko Kurokawa |
author_sort |
Shiro Takeda |
title |
Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action |
title_short |
Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action |
title_full |
Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action |
title_fullStr |
Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action |
title_full_unstemmed |
Antiallergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of antiallergic action |
title_sort |
antiallergic activity of probiotics from mongolian dairy products on type i allergy in mice and mode of antiallergic action |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2014-07-01 |
description |
Antiallergic activities of 10 lactic acid bacteria strains prepared from Mongolian dairy products as orally administered probiotics were examined in three murine type I allergy models (compound 48/80 stimulation, passive cutaneous anaphylaxis reaction, and ovalbumin sensitization models). Among the 10, only Lactobacillus plantarum strain 06CC2 significantly alleviated allergic symptoms in all three models and reduced the levels of total IgE, ovalbumin-specific IgE, and histamine in the sera of ovalbumin-sensitized mice. In vitro study, interferon-γ and interleukin-4 secretions from spleen cells of ovalbumin-sensitized mice administered the 06CC2 strain were significantly enhanced and suppressed, respectively, in the presence of ovalbumin. In Peyer's patches of ovalbumin-sensitized mice, strain 06CC2 significantly enhanced mRNA expressions of interferon-γ and interleukin-12 receptor β2, but suppressed that of the interleukin-4. Thus, strain 06CC2 probably promoted Th1 immunity through intestinal immunity and improved the Th1/Th2 balance in type I allergic mice, resulting in alleviation of allergic symptoms. |
topic |
Type I allergy Probiotics Mast cells Th1/Th2 balance Cytokine Peyer's patches |
url |
http://www.sciencedirect.com/science/article/pii/S1756464614001467 |
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