Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses

Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses

Background: Plasma concentration of natalizumab falls above the therapeutic threshold in many patients who, therefore, receive more natalizumab than necessary and have higher risk of progressive multifocal leukoencephalopathy.Objective: To assess in a single study the individual and treatment charac...

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Bibliographic Details
Main Authors: Jose M. Serra López-Matencio, Yaiza Pérez García, Virginia Meca-Lallana, Raquel Juárez-Sánchez, Angeles Ursa, Lorena Vega-Piris, Dora Pascual-Salcedo, Annick de Vries, Theo Rispens, Cecilia Muñoz-Calleja
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Neurology
Subjects:
natalizumab
pharmacokinetics
pharmacodynamics
multiple sclerosis
α4-integrin
dose scheme
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.716548/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.716548/full

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