Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues

Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues

Mitochondrial respiratory chain deficiency and mitochondrial DNA deletions are reported in substantia nigra neurons from healthy aged and Parkinson's disease cases, with extensive neuronal loss only seen in the latter. This study aimed to understand the pathological relevance of mitochondrial d...

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Bibliographic Details
Main Authors: Chun Chen, PhD, Amy E. Vincent, PhD, Alasdair P. Blain, PhD, Anna L. Smith, Doug M. Turnbull, PhD, FRCP, Amy K. Reeve, PhD
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
PD
mtDNA
Mitochondrial disease
POLG mutation
Neurodegeneration
Dopaminergic neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303067

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119303067

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