Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects.

BACKGROUND: Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level. DICER1, an RNAse III...

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Main Authors: Yannick Romero, Oliver Meikar, Marilena D Papaioannou, Béatrice Conne, Corinne Grey, Manuela Weier, François Pralong, Bernard De Massy, Henrik Kaessmann, Jean-Dominique Vassalli, Noora Kotaja, Serge Nef
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3187767?pdf=render