Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A<sub>2A</sub> Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS

Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A<sub>2A</sub> Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS

The authors in the current work suggested the potential repurposing of omarigliptin (OMR) for neurodegenerative diseases based on three new findings that support the preliminary finding of crossing BBB after a single dose study in the literature. The first finding is the positive results of the dock...

Full description

Bibliographic Details
Main Authors: Bassam M. Ayoub, Haidy E. Michel, Shereen Mowaka, Moataz S. Hendy, Mariam M. Tadros
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
repurposing
omarigliptin
docking
A2A adenosine receptor
acetylcholine esterase receptor
GLP-1
Online Access:https://www.mdpi.com/1420-3049/26/4/889

Internet

https://www.mdpi.com/1420-3049/26/4/889

Similar Items