NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication with severe long-term sequelae such as cerebral palsy, epilepsy and cognitive disabilities. Na+-K+-2Cl– cotransporters 1 (NKCC1) is dramatically upregulated after hypoxia-ischemia (HI), which aggravates brain edema and brain damag...

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Bibliographic Details
Main Authors: Xing-Liang Yang, Meng-Liu Zeng, Lin Shao, Guang-Tong Jiang, Jing-Jing Cheng, Tao-Xiang Chen, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He, Bi-Wen Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HI
neurons
NKCC1
NFAT5
HIF-1α
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00339/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00339/full

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