Synergistic Effect of Subtoxic-dose Cisplatin and TRAIL to Mediate Apoptosis by Down-regulating Decoy Receptor 2 and Up-regulating Caspase-8, Caspase-9 and Bax Expression on NCI-H460 and A549 Cells

Synergistic Effect of Subtoxic-dose Cisplatin and TRAIL to Mediate Apoptosis by Down-regulating Decoy Receptor 2 and Up-regulating Caspase-8, Caspase-9 and Bax Expression on NCI-H460 and A549 Cells

Objective(s): Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (NSCLC) exhibit TRAIL-resistance. The purpose of this study was to determine whether subtoxic-dose cis...

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Bibliographic Details
Main Authors: Xiaoyan Zhang, Jing Zhao, Wenyan Zhu, Hongfeng Gou, Dan Cao, Yu Yang, Ying Huang, Cheng Yi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2013-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Apoptosis Cisplatin DcR2 Nonsmall cell lung cancer Subtoxic-dose TRAIL
Online Access:http://ijbms.mums.ac.ir/pdf_785_c83ff34a4cca81b1affd5d1a0007de9a.html

Internet

http://ijbms.mums.ac.ir/pdf_785_c83ff34a4cca81b1affd5d1a0007de9a.html

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