ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis

ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis

Unfolded protein response (UPR) is crucial for both survival and death of mammalian cells, which is regulated by reactive oxygen species (ROS) and nutrient depletion. In this study, we demonstrated the effect of ROS-accumulation, induced by β-phenethyl isothiocyanate (PEITC), on UPR mediated apoptos...

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Bibliographic Details
Main Authors: Yoon-hee eHong, Md. Hafiz eUddin, Untek eJo, Boyun eKim, Dong Hoon eSuh, Hee Seung eKim, Jiyoung eSong, Yong Sang eSong
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Reactive Oxygen Species
Unfolded Protein Response
ovarian cancer
β-phenethyl isothiocyanate
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00167/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00167/full

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