Methylprednisolone Decreases Mitochondria-Mediated Apoptosis and Autophagy Dysfunction in Hepatocytes of Experimental Autoimmune Hepatitis Model via the Akt/mTOR Signaling

Methylprednisolone Decreases Mitochondria-Mediated Apoptosis and Autophagy Dysfunction in Hepatocytes of Experimental Autoimmune Hepatitis Model via the Akt/mTOR Signaling

Autoimmune hepatitis (AIH) is characterized by massive immune cell-mediated hepatocyte destruction. Glucocorticoids, particularly methylprednisolone (MP), are the most effective treatment for AIH; however, the mechanism underlying the effects of glucocorticoid treatment has not been fully elucidated...

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Bibliographic Details
Main Authors: Xiaoli Fan, Ruoting Men, Haoran Wang, Mengyi Shen, Tingting Wang, Tinghong Ye, Xuefeng Luo, Li Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
autoimmune hepatitis
methylprednisolone
LO2 cell
apoptosis
autophagy
Akt/mTOR signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01189/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01189/full

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