Glucocorticoids affect bone mineral density and bone remodelling in OVX sheep: A pilot study

The aim of this study was to validate the combination of ovariectomy and glucocorticoid treatment in sheep as a large animal model for osteoporosis by measuring the concentration of specific biomarkers in the blood of the sheep and measuring bone loss over five months. Aged Merino ewes were randomly...

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Bibliographic Details
Main Authors: Diana Cabrera, Frances M. Wolber, Keren Dittmer, Chris Rogers, Anne Ridler, Danielle Aberdein, Tim Parkinson, Paul Chambers, Karl Fraser, Nicole C. Roy, Marlena Kruger
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Bone Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S235218721830055X