Glucocorticoids affect bone mineral density and bone remodelling in OVX sheep: A pilot study

Glucocorticoids affect bone mineral density and bone remodelling in OVX sheep: A pilot study

The aim of this study was to validate the combination of ovariectomy and glucocorticoid treatment in sheep as a large animal model for osteoporosis by measuring the concentration of specific biomarkers in the blood of the sheep and measuring bone loss over five months. Aged Merino ewes were randomly...

Full description

Bibliographic Details
Main Authors:	Diana Cabrera, Frances M. Wolber, Keren Dittmer, Chris Rogers, Anne Ridler, Danielle Aberdein, Tim Parkinson, Paul Chambers, Karl Fraser, Nicole C. Roy, Marlena Kruger
Format:	Article
Language:	English
Published:	Elsevier 2018-12-01
Series:	Bone Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S235218721830055X

Similar Items

Effects of short- and long-term glucocorticoid-induced osteoporosis on plasma metabolome and lipidome of ovariectomized sheep
by: Diana Cabrera, et al.
Published: (2020-06-01)

Correction to: Effects of short- and long-term glucocorticoid-induced osteoporosis on plasma metabolome and lipidome of ovariectomized sheep
by: Diana Cabrera, et al.
Published: (2020-07-01)

The effects of isoflavone and ozagrel on bone metabolism in ovx mice
by: Yi-Min Liu, et al.
Published: (2011)

Osteoporosis: Modern Paradigms for Last Century’s Bones
by: Marlena C. Kruger, et al.
Published: (2016-06-01)

Preventive Effects of Citrus unshiu Peel Extracts on Bone and Lipid Metabolism in OVX Rats
by: Dong Wook Lim, et al.
Published: (2014-01-01)

Potential bone healing by ST1 through osteogenesis in OVX-SAMP8 mice
by: Alice Liu, et al.
Published: (2015)

Nox4 Expression Is Not Required for OVX‐Induced Osteoblast Senescence and Bone Loss in Mice
by: Jin‐Ran Chen, et al.
Published: (2020-08-01)

Influence of glucocorticoid treatment on trabecular bone score and bone remodeling regulators in early rheumatoid arthritis
by: Addolorata Corrado, et al.
Published: (2021-07-01)

Cistanche deserticola polysaccharide inhibits OVX-induced bone loss in mice and RANKL-induced osteoclastogenesis
by: Wen Xiao, et al.
Published: (2021-06-01)

Dihydromyricetin induces white adipose tissue browning and inhibits OVX and LPS-induced bone loss
by: Xuejun Zhang, et al.
Published: (2016-10-01)

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice
by: Leena Sapra, et al.
Published: (2021-01-01)

Violations of cell-molecular mechanisms of bone remodeling under influence of glucocorticoids
by: S. B. Pavlov, et al.
Published: (2018-02-01)

Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling
by: A. Sean Alemi, et al.
Published: (2018-12-01)

Seasonal and Anatomical Variation in Compact Bone Remodeling in the Adult Sheep
by: Calcagno, Joseph
Published: (2011)

The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice
by: Xiang Li, et al.
Published: (2019-10-01)

Hi dietary salt intake induces bone loss in Ovx mice by skewing Treg-Th17 balance
by: K. Srivastava Rupesh, et al.
Published: (2017-09-01)

Lactobacillus Acidophilus enhances trabecular and cortical bone microarchitecture in ovx mice via modulating host immune system
by: Y. Dar Hamid, et al.
Published: (2017-09-01)

Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley Rats
by: Amanda B. Longo, et al.
Published: (2016-09-01)

Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies
by: Umani S. Walallawita, et al.
Published: (2020-09-01)

BONE REMODELING IN NORM AND IN PRIMARY OSTEOPOROSIS: THE SIGNIFICANCE OF BONE REMODELING MARKERS
by: G. M. Nurullina, et al.
Published: (2018-03-01)

Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study
by: Diana Cabrera, et al.
Published: (2018-05-01)

RETINOID RECEPTORS IN BONE AND THEIR ROLE IN BONE REMODELING
by: Petra eHenning, et al.
Published: (2015-03-01)

Mediators in bone remodelling
by: Willmott, Corrine Sophie
Published: (2005)

Vitamin D Auto-/Paracrine System Is Involved in Modulation of Glucocorticoid-Induced Changes in Angiogenesis/Bone Remodeling Coupling
by: Olha Lisakovska, et al.
Published: (2020-01-01)

Glucocorticoids prolong the reversal-resorption phase delaying bone formation in intracortical remodelling compared to postmenopausal and osteoporotic women
by: Lisbeth Koch Thomsen, et al.
Published: (2021-04-01)

Bone Strength/Bone Mass Discrepancy in Glucocorticoid‐Treated Adult Mice
by: Alanna M. Dubrovsky, et al.
Published: (2021-03-01)

Effects of Glucocorticoid on Bone Metabolism Markers and Bone Mineral Density in Rats.
by: A. Sobhani, et al.
Published: (2005-06-01)

Effects of Glucocorticoid on Bone Metabolism Markers and Bone Mineral Density in Rats
by: A. Sobhani, et al.
Published: (2005-06-01)

Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
by: Porter, Ryan Michael
Published: (2014)

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling
by: Kaixuan Chen, et al.
Published: (2020-12-01)

Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe
by: Claire S. Martin, et al.
Published: (2021-08-01)

Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner
by: Inbar Hillel, et al.
Published: (2017-01-01)

Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway
by: Wei Zhou, et al.
Published: (2019-01-01)

Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity
by: Bo Li, et al.
Published: (2020-12-01)

Bone remodeling by checkpoint inhibitor
by: Hyeongjong Kim, et al.
Published: (2020-09-01)

Deubiquitinating Enzymes and Bone Remodeling
by: Yu-chen Guo, et al.
Published: (2018-01-01)

Phytoestrogenic molecule icaritin prevents OVX-induced osteoporosis in mice
by: Jing Long, et al.
Published: (2014-10-01)

The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease
by: Christos Masaoutis, et al.
Published: (2019-01-01)

Bone status in patients with epilepsy: relationship to markers of bone remodeling
by: Sherifa Ahmed Hamed, et al.
Published: (2014-08-01)

Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption
by: Brendan F. Boyce, et al.
Published: (2018-09-01)