Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation.

Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation.

The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate into the mature...

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Bibliographic Details
Main Authors: Rafaela C Sartore, Priscila B Campos, Cleber A Trujillo, Bia L Ramalho, Priscilla D Negraes, Bruna S Paulsen, Tamara Meletti, Elaine S Costa, Leonardo Chicaybam, Martin H Bonamino, Henning Ulrich, Stevens K Rehen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3108948?pdf=render

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http://europepmc.org/articles/PMC3108948?pdf=render

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