CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

Summary: CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP function was ablated using gene-editing and an unbiased...

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Main Authors: Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
cell biology
organizational aspects of cell biology
bioinformatics
omics
proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008464

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http://www.sciencedirect.com/science/article/pii/S2589004221008464

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