Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133+/EpCAM+ phenotype: a promising target for preventing progression of TNBC

Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133+/EpCAM+ phenotype: a promising target for preventing progression of TNBC

Abstract Background The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate with breast tumor aggressiveness, suggesting that simultaneous targeti...

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Bibliographic Details
Main Authors: Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani, Valeria Bertagnolo
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Cancer
Subjects:
Triple-negative breast cancer (TNBC)
CD133
EpCAM
PLC-β2
Breast cancer stem cell (BCSC)
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12885-017-3592-y

Internet

http://link.springer.com/article/10.1186/s12885-017-3592-y

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