CYP2D7 sequence variation interferes with TaqMan CYP2D6*15 and *35 genotyping

CYP2D7 sequence variation interferes with TaqMan CYP2D6*15 and *35 genotyping

TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNP...

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Bibliographic Details
Main Authors: Amanda K Riffel, Mehdi eDehghani, Toinette eHartshorne, Kristen eFloyd, J Steven eLeeder, Kevin P Rosenblatt, Andrea eGaedigk
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Pharmacology
Subjects:
CYP2D6
genotyping
TaqMan
CYP2D7
CYP2D6*15
CYP2D6*35
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00312/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00312/full

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