Epitope mapping for monoclonal antibody reveals the activation mechanism for αVβ3 integrin.

Epitopes for a panel of anti-αVβ3 monoclonal antibodies (mAbs) were investigated to explore the activation mechanism of αVβ3 integrin. Experiments utilizing αV/αIIb domain-swapping chimeras revealed that among the nine mAbs tested, five recognized the ligand-binding β-propeller domain and four recog...

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Bibliographic Details
Main Authors: Tetsuji Kamata, Makoto Handa, Sonomi Takakuwa, Yukiko Sato, Yohko Kawai, Yasuo Ikeda, Sadakazu Aiso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3688720?pdf=render