High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

Glutamate excitotoxicity is a consolidated hypothesis in neonatal brain injuries and tissue plasminogen activator (t-PA) participates in the processes through proteolytic and receptor mediated effects. In brain microvascular endothelial cell (nBMEC) cultures from neonates, t-PA content and release u...

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Bibliographic Details
Main Authors: Vincent Jean Henry, Maryline Lecointre, Vincent Laudenbach, Carine Ali, Richard Macrez, Amandine Jullienne, Vincent Berezowski, Peter Carmeliet, Denis Vivien, Stéphane Marret, Bruno José Gonzalez, Philippe Leroux
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Neurobiology of Disease
Subjects:
Brain development
Microvessels
Vascular endothelium
Glutamate
Tissue plasminogen activator
Neuronal death
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003488

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http://www.sciencedirect.com/science/article/pii/S0969996112003488

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