CCR2 deficiency alters activation of microglia subsets in traumatic brain injury

CCR2 deficiency alters activation of microglia subsets in traumatic brain injury

Summary: In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cells have the potential to worsen damage and/or to assist in healing. We define the heterogeneity of microglia and macrophage phenotypes during TBI in wild-type (WT) mice and Ccr2−/− mice, which...

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Bibliographic Details
Main Authors: Kerri Somebang, Joshua Rudolph, Isabella Imhof, Luyi Li, Erene C. Niemi, Judy Shigenaga, Huy Tran, T. Michael Gill, Iris Lo, Brian A. Zabel, Gabriela Schmajuk, Brian T. Wipke, Stefka Gyoneva, Luke Jandreski, Michael Craft, Gina Benedetto, Edward D. Plowey, Israel Charo, James Campbell, Chun Jimmie Ye, S. Scott Panter, Mary C. Nakamura, Walter Eckalbar, Christine L. Hsieh
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
microglia
macrophages
monocytes
dendritic cells
traumatic brain injury
neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011761

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http://www.sciencedirect.com/science/article/pii/S2211124721011761

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