11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

Summary: High-risk neuroblastomas typically display an undifferentiated or poorly differentiated morphology. It is therefore vital to understand molecular mechanisms that block the differentiation process. We identify an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of und...

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Bibliographic Details
Main Authors: Joachim Tetteh Siaw, Niloufar Javanmardi, Jimmy Van den Eynden, Dan Emil Lind, Susanne Fransson, Angela Martinez-Monleon, Anna Djos, Rose-Marie Sjöberg, Malin Östensson, Helena Carén, Gunhild Trøen, Klaus Beiske, Ana P. Berbegall, Rosa Noguera, Wei-Yun Lai, Per Kogner, Ruth H. Palmer, Bengt Hallberg, Tommy Martinsson
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports
Subjects:
ALK
neuroblastoma
DLG2
tumor suppressor
retinoic acid
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720311608

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http://www.sciencedirect.com/science/article/pii/S2211124720311608

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