Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

Disease modeling requires appropriate cellular models that best mimic the underlying pathophysiology. Human origin and an adequate expression of the disease protein are pre-requisites that support information from a model to be meaningful. In this study we investigated expression profiles of (i) PBM...

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Bibliographic Details
Main Authors: Stefan Hauser, Stefanie Schuster, Elena Heuten, Philip Höflinger, Jakob Admard, Yvonne Schelling, Ana Velic, Boris Macek, Stephan Ossowski, Ludger Schöls
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
motor neuron disorders
hereditary spastic paraplegia
amyotrophic lateral sclerosis
spinal muscular atrophy
gene expression
iPSCs
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.544043/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.544043/full

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