Structural Biology of the TNFα Antagonists Used in the Treatment of Rheumatoid Arthritis

Structural Biology of the TNFα Antagonists Used in the Treatment of Rheumatoid Arthritis

The binding of the tumor necrosis factor α (TNFα) to its cognate receptor initiates many immune and inflammatory processes. The drugs, etanercept (Enbrel®), infliximab (Remicade®), adalimumab (Humira®), certolizumab-pegol (Cimzia®), and golimumab (Simponi®), are anti-TNFα agents. These drugs block T...

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Bibliographic Details
Main Authors: Heejin Lim, Sang Hyung Lee, Hyun Tae Lee, Jee Un Lee, Ji Young Son, Woori Shin, Yong-Seok Heo
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
TNFα
etanercept
infliximab
adalimumab
certolizumab pegol
golimumab
rheumatoid arthritis
therapeutic antibody
structure
Online Access:http://www.mdpi.com/1422-0067/19/3/768

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http://www.mdpi.com/1422-0067/19/3/768

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