Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells

Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells

Abstract Background Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). Accordingly, long term cultures of isolated OSE cells undergo in...

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Bibliographic Details
Main Authors: Ulises Urzúa, Sandra Ampuero, Katherine F. Roby, Garrison A. Owens, David J. Munroe
Format: Article
Language:English
Published: BMC 2016-10-01
Series:BMC Genomics
Subjects:
Ovarian cancer model
Preneoplasia
Mouse ovarian surface epithelium
Transcriptome
Genome
Aneuploidy
Online Access:http://link.springer.com/article/10.1186/s12864-016-3068-5

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http://link.springer.com/article/10.1186/s12864-016-3068-5

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