Interferon-alpha administration enhances CD8+ T cell activation in HIV infection.

Interferon-alpha administration enhances CD8+ T cell activation in HIV infection.

Type I interferons play important roles in innate immune defense. In HIV infection, type I interferons may delay disease progression by inhibiting viral replication while at the same time accelerating disease progression by contributing to chronic immune activation.To investigate the effects of type...

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Bibliographic Details
Main Authors: Maura Manion, Benigno Rodriguez, Kathleen Medvik, Gareth Hardy, Clifford V Harding, Robert T Schooley, Richard Pollard, David Asmuth, Robert Murphy, Edward Barker, Kirsten E Brady, Alan Landay, Nick Funderburg, Scott F Sieg, Michael M Lederman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3265460?pdf=render

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http://europepmc.org/articles/PMC3265460?pdf=render

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