m<sup>5</sup>U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

m<sup>5</sup>U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs

Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regul...

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Bibliographic Details
Main Authors: Marisa Pereira, Diana R. Ribeiro, Miguel M. Pinheiro, Margarida Ferreira, Stefanie Kellner, Ana R. Soares
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
tRNAs
tRNA-modifying enzyme
TRMT2A
methyltransferase
tRNA hypomethylation
tRNA-derived small RNAs
Online Access:https://www.mdpi.com/1422-0067/22/6/2941

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https://www.mdpi.com/1422-0067/22/6/2941

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