Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to he...

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Bibliographic Details
Main Authors: Daniel M Spagnolo, Rekha Gyanchandani, Yousef Al-Kofahi, Andrew M Stern, Timothy R Lezon, Albert Gough, Dan E Meyer, Fiona Ginty, Brion Sarachan, Jeffrey Fine, Adrian V Lee, D Lansing Taylor, S Chakra Chennubhotla
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Journal of Pathology Informatics
Subjects:
Computational pathology
multiplexed immunofluorescence
pointwise mutual information
tumor heterogeneity
tumor microenvironment
Online Access:http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2016;volume=7;issue=1;spage=47;epage=47;aulast=Spagnolo

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http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2016;volume=7;issue=1;spage=47;epage=47;aulast=Spagnolo

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