Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment

Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment

World Trade Center particulate matter (WTC-PM)-exposed firefighters with metabolic syndrome (MetSyn) have a higher risk of WTC lung injury (WTC-LI). Since macrophages are crucial innate pulmonary mediators, we investigated WTC-PM/lysophosphatidic acid (LPA) co-exposure in macrophages. LPA, a low-den...

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Bibliographic Details
Main Authors: Rachel Lam, Syed H. Haider, George Crowley, Erin J. Caraher, Dean F. Ostrofsky, Angela Talusan, Sophia Kwon, David J. Prezant, Yuyan Wang, Mengling Liu, Anna Nolan
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Environmental Research and Public Health
Subjects:
lysophosphatidic acid
particulate matter exposure
RAGE
synergy
Online Access:https://www.mdpi.com/1660-4601/17/12/4318

Internet

https://www.mdpi.com/1660-4601/17/12/4318

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