Biomarker recommendation for PD‐1/PD‐L1 immunotherapy development in pediatric cancer based on digital image analysis of PD‐L1 and immune cells

Abstract Anti‐PD‐1/PD‐L1 immunotherapy could offer an alternative to traditional chemo‐ and/or radiotherapy to treat pediatric cancer patients. To unveil the potential benefit of this new therapeutic approach, the prevalence of PD‐L1 and other relevant immune markers using quantitative digital image...

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Bibliographic Details
Main Authors: Manuel A Silva, Nicolas Triltsch, Simon Leis, Ivan Kanchev, Tze Heng Tan, Benjamine Van Peel, Marian Van Kerckhoven, Vanessa Deschoolmeester, Johannes Zimmermann
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:The Journal of Pathology: Clinical Research
Subjects:
CD3
CD8
Online Access:https://doi.org/10.1002/cjp2.152