1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression

1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression

Multiple myeloma (MM) still remains an incurable disease, therefore discovery of novel drugs boosts the therapeutics for MM. The natural compound 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranoside (PGG) has been shown to exhibit antitumor activities against various cancer cells. Here, we aim to evalua...

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Bibliographic Details
Main Authors: Duurenjargal Tseeleesuren, Rajni Kant, Chia-Hung Yen, Hui-Hua Hsiao, Yi-Ming A. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
multiple myeloma
MYC
PGG
DEPTOR
G1 arrest
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00065/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00065/full

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