EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis

EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis

Abstract Background Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, the peritoneal metastasis, and the relapse, but also for the acquisition of chemotherapy resistance. Nevertheless, figuring out their phenotypic...

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Bibliographic Details
Main Authors: Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Ovarian cancer
Cancer stem cells
Chemoresistance
EIF5A2
E2F1
KLF4
Online Access:https://doi.org/10.1186/s13287-021-02256-2

Internet

https://doi.org/10.1186/s13287-021-02256-2

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