ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner

ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner

Several epidemiological studies reported that chronic arsenic exposure increased risk of prostate cancer. This study aimed to investigate whether chronic NaAsO2 exposure elevates stemness and chemoresistance in prostate cancer cells. DU145 (wild-type p53) and PC-3 (p53-null) cells were exposed to Na...

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Bibliographic Details
Main Authors: Zhi-Hui Zhang, Qian Hong, Zhi-Cheng Zhang, Wei-Yang Xing, Shen Xu, Qi-Xing Tian, Qing-Lin Ye, Hua Wang, De-Xin Yu, Dong-Dong Xie, De-Xiang Xu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
NaAsO2
Genotoxic stress
Stemness
Chemoresistance
Prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320312732

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http://www.sciencedirect.com/science/article/pii/S0147651320312732

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