Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia

Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer derived from the malignant transformation of T-cell progenitors. Outcomes remain poor for T-ALL patients who have either primary resistance to standard-of-care chemotherapy or disease relapse. Notably, there are currentl...

Full description

Bibliographic Details
Main Authors: Jie Gao, Michael Van Meter, Susana Hernandez Lopez, Guoying Chen, Ying Huang, Shumei Ren, Qi Zhao, Jose Rojas, Cagan Gurer, Gavin Thurston, Frank Kuhnert
Format: Article
Language:English
Published: The Company of Biologists 2019-09-01
Series:Disease Models & Mechanisms
Subjects:
T-ALL
Notch1
Targeted therapy
PD-1 blockade
Immunotherapy
Online Access:http://dmm.biologists.org/content/12/9/dmm040931

Internet

http://dmm.biologists.org/content/12/9/dmm040931

Similar Items