HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.

HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.

N6-methyladenosine (m6A) is the most abundant HIV RNA modification but the interplay between the m6A reader protein YTHDF3 and HIV replication is not well understood. We found that knockout of YTHDF3 in human CD4+ T-cells increases infection supporting the role of YTHDF3 as a restriction factor. Ove...

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Bibliographic Details
Main Authors: Denise Jurczyszak, Wen Zhang, Sandra N Terry, Thomas Kehrer, Maria C Bermúdez González, Emma McGregor, Lubbertus C F Mulder, Matthew J Eckwahl, Tao Pan, Viviana Simon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008305

Internet

https://doi.org/10.1371/journal.ppat.1008305

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