Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

Abstract Background One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropriately, however, ingestion of just a few milligrams of fentanyl or other...

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Bibliographic Details
Main Authors: Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek, Thomas E. Prisinzano
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Biomedical Science
Subjects:
Structure–activity relationship
MOR antagonist
Fentanyl
Naltrexone
Antinociceptive activity
Online Access:https://doi.org/10.1186/s12929-021-00758-y

Internet

https://doi.org/10.1186/s12929-021-00758-y

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