A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System

A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System

Cytolytic pore-forming toxins including alpha hemolysin (Hla) and bicomponent leukotoxins play an important role in the pathogenesis of Staphylococcus aureus. These toxins kill the polymorphonuclear phagocytes (PMNs), disrupt epithelial and endothelial barriers, and lyse erythrocytes to provide iron...

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Bibliographic Details
Main Authors: Arundhathi Venkatasubramaniam, Tulasikumari Kanipakala, Nader Ganjbaksh, Rana Mehr, Ipsita Mukherjee, Subramaniam Krishnan, Taeok Bae, M. Javad Aman, Rajan P. Adhikari
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxins
Subjects:
S. aureus
hlgA
hla
leukotoxins
Newman
SaeS
agr
Online Access:http://www.mdpi.com/2072-6651/10/9/377

Internet

http://www.mdpi.com/2072-6651/10/9/377

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