Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue.

Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue.

Alpha-dystroglycan requires a rare O-mannose glycan modification to form its binding epitope for extracellular matrix proteins such as laminin. This functional glycan is disrupted in a cohort of muscular dystrophies, the secondary dystroglycanopathies, and is abnormal in some metastatic cancers. The...

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Main Authors: Marisa J Fortunato, Charlotte E Ball, Katrin Hollinger, Niraj B Patel, Jill N Modi, Vedika Rajasekaran, Dan J Nonneman, Jason W Ross, Eileen J Kennedy, Joshua T Selsby, Aaron M Beedle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4019581?pdf=render

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http://europepmc.org/articles/PMC4019581?pdf=render

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