Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function

Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function

Background: The gut microbiome has been linked to the onset of cardiometabolic diseases, in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N-oxide. However, molecular pathways associated to heart failure mediated by microbial metabolites remain largely elusive....

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Bibliographic Details
Main Authors: Maren Gesper, Alena B. H. Nonnast, Nina Kumowski, Robert Stoehr, Katharina Schuett, Nikolaus Marx, Ben A. Kappel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Medicine
Subjects:
gut microbiota
microbial metabolites
heart failure
mitochondrial dysfunction
cardiomyocyte physiology
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.648259/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.648259/full

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