Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth

Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth

Pancreatic ductal adenocarcinoma (PDAC) remains an unmet clinical problem in urgent need of newer molecularly driven treatment modalities. Calcium signals, particularly those associated with calcium release-activated calcium (CRAC) channels, are known to influence the development, growth, and metast...

Full description

Bibliographic Details
Main Authors: Husain Yar Khan, Gabriel B. Mpilla, Rachel Sexton, Srikant Viswanadha, Kumar V. Penmetsa, Amro Aboukameel, Maria Diab, Mandana Kamgar, Mohammed Najeeb Al-Hallak, Mark Szlaczky, Anteneh Tesfaye, Steve Kim, Philip A. Philip, Ramzi M. Mohammad, Asfar S. Azmi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
crac channel
orai1
stim
pancreatic cancer
novel therapy
Online Access:https://www.mdpi.com/2072-6694/12/3/750

Internet

https://www.mdpi.com/2072-6694/12/3/750

Similar Items