A rapid RP-HPLC method for the simultaneous estimation of Ivacaftor and Tezacaftor and in silico study of their metabolitic products

A rapid RP-HPLC method for the simultaneous estimation of Ivacaftor and Tezacaftor and in silico study of their metabolitic products

Abstract Background This study was designed to develop a reliable method for estimation of Ivacaftor and Tezacaftor in pure and its pharmaceutical dosage form by RP-HPLC in human plasma. Molecular docking studies were carried out and the results were visualized using PyMol and Discovery studio visua...

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Bibliographic Details
Main Authors: Madhuri Donakonda, Srija Indrakanti, Praveen Kumar Pasala, Malleswari Desari, Shireesha Kammari
Format: Article
Language:English
Published: SpringerOpen 2021-06-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Tezacaftor
Ivacaftor
In silico docking
Human plasma
RP-HPLC metabolites
Online Access:https://doi.org/10.1186/s43094-021-00254-y

Internet

https://doi.org/10.1186/s43094-021-00254-y

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