Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.

Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.

The Prader-Willi syndrome (PWS [MIM 17620]) and Angelman syndrome (AS [MIM 105830]) locus is controlled by a bipartite imprinting center (IC) consisting of the PWS-IC and the AS-IC. The most widely accepted model of IC function proposes that the PWS-IC activates gene expression from the paternal all...

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Bibliographic Details
Main Authors: Emily Y Smith, Christopher R Futtner, Stormy J Chamberlain, Karen A Johnstone, James L Resnick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3248558?pdf=render

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http://europepmc.org/articles/PMC3248558?pdf=render

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