Delta Like-1 Gene Mutation: A Novel Cause of Congenital Vertebral Malformation

Delta Like-1 Gene Mutation: A Novel Cause of Congenital Vertebral Malformation

Skeletal development throughout the embryonic and postnatal phases is a dynamic process, based on bone remodeling and the balance between the activities of osteoclasts and osteoblasts modulating skeletal homeostasis. The Notch signaling pathway is a regulator of several developmental processes, and...

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Bibliographic Details
Main Authors: Tlili Barhoumi, Marwan Nashabat, Bandar Alghanem, AlShaimaa Alhallaj, Mohamed Boudjelal, Muhammad Umair, Saud Alarifi, Ahmed Alfares, Saad A. Al Mohrij, Majid Alfadhel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Genetics
Subjects:
bone development
congenital vertebral malformation
Delta Like-1
Notch signaling pathway
scoliosis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00534/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00534/full

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