p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its canonical roles. p53 deficiency sensitizes cells to Topoisomerase...

Full description

Bibliographic Details
Main Authors: Constance Qiao Xin Yeo, Irina Alexander, Zhaoru Lin, Shuhui Lim, Obed Akwasi Aning, Ramesh Kumar, Kanda Sangthongpitag, Vishal Pendharkar, Vincent H.B. Ho, Chit Fang Cheok
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302522

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716302522

Similar Items