High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies

High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies

Background: Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized sarcoma subtype. This study aims to assess UPS molecular characteristics and identify specific therapeutic targets. Methods: High-throughput technologies encompassing immunohistochemistry,...

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Bibliographic Details
Main Authors: Maud Toulmonde, Carlo Lucchesi, Stéphanie Verbeke, Amandine Crombe, Julien Adam, Damien Geneste, Vanessa Chaire, Audrey Laroche-Clary, Raul Perret, François Bertucci, Frederic Bertolo, Laurence Bianchini, Bérengère Dadone-Montaudie, Todd Hembrough, Steve Sweet, Yeoun Jin Kim, Fabiola Cecchi, François Le Loarer, Antoine Italiano
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:EBioMedicine
Subjects:
Sarcomas
Genomics
Immunology
Proteomics
Preclinical
Therapeutic targets
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305077

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http://www.sciencedirect.com/science/article/pii/S2352396420305077

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