Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation

Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation

Sirolimus (SRL) is widely used to prevent restenosis after percutaneous coronary intervention. However, its beneficial effect is hampered by complications of thrombosis. Several studies imply that reactive oxygen species (ROS) play a critical role in endothelial dysfunction and thrombus formation. T...

Full description

Bibliographic Details
Main Authors: Ken Aizawa, Youko Takahari, Naoko Higashijima, Kenichi Serizawa, Kenji Yogo, Nobuhiko Ishizuka, Koichi Endo, Naoto Fukuyama, Katsuya Hirano, Hideyuki Ishida
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Nicorandil
Sirolimus
Thrombosis
Reactive oxygen species
Endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315000341

Internet

http://www.sciencedirect.com/science/article/pii/S1347861315000341

Similar Items