Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples o...

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Bibliographic Details
Main Authors: Yuka Nadai, Kathrin Held, Sarah Joseph, Mohamed I. M. Ahmed, Verena S. Hoffmann, David Peterhoff, Marco Missanga, Asli Bauer, Agricola Joachim, Ulf Reimer, Johannes Zerweck, Sheena McCormack, Alethea V. Cope, Roger Tatoud, Robin J. Shattock, Merlin Lee Robb, Eric G. Sandstroem, Michael Hoelscher, Leonard Maboko, Muhammad Bakari, Arne Kroidl, Ralf Wagner, Jonathan Weber, Georgios Pollakis, Christof Geldmacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
HIV
vaccine
envelope-specific antibodies
epitope variant recognition
immunogen structure
immunogen sequence
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00717/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00717/full

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