Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

Abstract Background Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, whether DHA causes ferroptosis in glioma cells and the potential regulatory...

Full description

Bibliographic Details
Main Authors: Yibing Chen, Yanjun Mi, Xiaofei Zhang, Qian Ma, Yucen Song, Liwei Zhang, Dandan Wang, Jinliang Xing, Benxin Hou, Haolong Li, Huan Jin, Wei Du, Zhengzhi Zou
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Dihydroartemisinin
Ferroptosis
GPX4
Endoplasmic reticulum stress
HSPA5
Glioma
Online Access:http://link.springer.com/article/10.1186/s13046-019-1413-7

Internet

http://link.springer.com/article/10.1186/s13046-019-1413-7

Similar Items