Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents

Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opioids. Endoplasmic reticulum (ER) stress has been shown to contribute to neuropathic or inflammatory pain, but its roles in opioids-induced hyperalgesia (OIH) are el...

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Bibliographic Details
Main Authors: Tong-Tong Lin, Jie Qu, Chao-Yu Wang, Xing Yang, Fan Hu, Liang Hu, Xue-Feng Wu, Chun-Yi Jiang, Wen-Tao Liu, Yuan Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
opioids-induced hyperalgesia
endoplasmic reticulum stress
unfolded protein response
HSP70
PKA
NR1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00269/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00269/full

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