High Dose Atorvastatin Associated with Increased Risk of Significant Hepatotoxicity in Comparison to Simvastatin in UK GPRD Cohort.

BACKGROUND & AIMS:Occasional risk of serious liver dysfunction and autoimmune hepatitis during atorvastatin therapy has been reported. We compared the risk of hepatotoxicity in atorvastatin relative to simvastatin treatment. METHODS:The UK GPRD identified patients with a first prescription for s...

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Bibliographic Details
Main Authors: Alan T Clarke, Paul C D Johnson, Gillian C Hall, Ian Ford, Peter R Mills
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4794178?pdf=render