Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches t...
Main Authors: | Simon Haworth, Ruth Mitchell, Laura Corbin, Kaitlin H. Wade, Tom Dudding, Ashley Budu-Aggrey, David Carslake, Gibran Hemani, Lavinia Paternoster, George Davey Smith, Neil Davies, Daniel J. Lawson, Nicholas J. Timpson |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-08219-1 |
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