Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-<i>O</i>-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes respons...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/23/12/3252 |