Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-<i>O</i>-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes respons...
Main Authors: | Keith D. Green, Marina Y. Fosso, Sylvie Garneau-Tsodikova |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-12-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/23/12/3252 |
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